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CEN/TS 16826-1:2015

Molecular in vitro diagnostic examinations - Specifications for pre-examination processes for snap frozen tissue - Part 1: Isolated RNA

General information

Withdrawn from 03.01.2019
Base Documents
CEN/TS 16826-1:2015
Directives or regulations
None

Standard history

Status
Date
Type
Name
03.01.2019
Main
02.09.2015
Main
This Technical Specification recommends the handling, documentation and processing of frozen tissue specimens intended for RNA analysis during the preanalytical phase before a molecular assay is performed. This Technical Specification is applicable to molecular in vitro diagnostic examinations (e.g., in vitro diagnostic laboratories, laboratory customers, in vitro diagnostics developers and manufacturers, institutions and commercial organisations performing biomedical research, biobanks, and regulatory authorities).
RNA profiles in tissues can change significantly before and after collection and can change differently in different donors’ / patients’ tissues.
Therefore, special measures have to be taken to minimize the described profile changes and modifications within the tissue for subsequent RNA analysis.
Tissues that have undergone chemical stabilisation pre-treatment before freezing are not covered in this document.

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